Structural Elucidation

Structural Elucidation 1

Identifying unknown impurities and metabolites

The marriage of significant analytical capabilities with the experience of our scientific personnel allows for the isolation and characterization of sub-microgram quantities of impurities during process optimization and purified materials.

Capabilities

  • Crystallization: increase the relative amount of impurity in mother liquor
  • Biotage and ISCO preparative normal and reverse phase LC
  • Forced Degradation: increase impurity level
  • Waters Preparative LC-UV-MS with mass-directed capabilities
  • Crystallization: suitable for single crystal X-ray analysis
  • Impurity Synthesis

Personnel and Experience

  • 3 NMR Spectroscopists (82 years collective experience)
  • 1 Single Crystal Diffractometer Expert (25 years experience)
  • 35 Process Chemists
  • 10 Analytical Chemists
  • 7 Crystallization scientists

Equipment

  • 4 x NMR systems (1 x 300 MHz / 2 x 400 MHz / 1 x 500 MHz)
  • >30 HPLC/UPLC systems and 4 CAD units
  • 7 x HPLC/UPLC-MS and 3 x GM-MS
  • 1 x UPLC-Orbitrap MS (accurate mass) new in 2018
  • Single Crystal X-ray Diffractometer new in 2018

In this Section