LED BY PASSIONATE EXPERTS

Partnering with the 
Pharmaceutical Industry to
Make New Therapies Possible

The Industry Leader
in Small Molecule Process Research
and Crystallization R&D

Welcome to J-STAR Research, Inc.

Our mission is to help pharmaceutical small molecule R&D programs succeed in all phases of development.

Andrew S. Thompson, Ph.D. President
Andrew S. Thompson, Ph.D. President

We’ll ensure you always get the best Results.

Founded in 1996, J-STAR Research has assembled one of the most talented and experienced chemical process teams in the industry.
Synthetic Chemists
Analytical Chemists
Crystallization R&D/Solid Form Staff
GMP Staff

Contract Research & Development Services

J-STAR Research provides a wide range of small molecule chemistry capabilities and technologies, including:

Process Chemistry R&D

Process Chemistry R&D

The focus of the company is on helping the pharmaceutical industry to develop scalable, robust and economically feasible syntheses supporting small molecule pre-clinical development.

  • Develop cost-efficient syntheses
  • Problem-solving capabilities that lead to novel solutions
  • Quickly develop phase appropriate syntheses
  • Remove hazardous chemistry
  • Developing robust crystallization solutions

Analytical R&D and Quality Control

Analytical R&D and Quality Control

Our Analytical Research team provides all of the analytical needs for process development, GLP studies and GMP campaigns. In general, our service includes, but is not limited to, method development, method verification / validation, reference standard certification, release testing, and impurity separation and identification.

  • HPLC / GC method development for challenging separations including chiral separations
  • Method development and testing using LC/MS LC/ELSD GC/FID GC/MS NMR TGA KF DSC FT-IR Polarimeter
  • Method transfer / validation
  • Reference standard certification
  • Separation and Characterization of impurities and degradants
  • Raw material
  • Intermediate and API release testing
  • Stability studies: stability indicating method development and stability sample testing

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Crystallization R&D

As one of the oldest unit operations known to mankind, crystallization today is a leading method for efficient isolation of drug substances with high purity and desired solid state characteristics, to ensure efficacy and safety of drug products.

  • Crystallization Process Development
  • Particle Engineering & Co-Processing
  • Solid Form Screen & Studies
  • Pre-Formulation Evaluations

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Drug Product and Formulation Science and Technology

Seamlessly and in parallel with our crystallization experts develop rugged processes and formulations that follow rigorous QbD procedures, fundamentals of material science and fit-for-purpose enabling technologies.

  • Solid state and powder characterization
  • Pre-formulation and pre-clinical packages
  • Phase 1 formulation development and supply
  • Formulation development for on-site compounding clinical CRO
  • Phase 2 and 3 formulation and process development
  • Spray drying technology platform
  • HME technology platform
  • Co-processing technology platform
  • Co-processing to enable facility light high potency API handling

Catalyst Screening

Catalyst Screening

Our services in catalysis reaction development are differentiated through our integrated approach in the overall process development. We develop efficient catalytic reactions by utilizing the newest tools together with verified experimental high throughput techniques, scientific and industrial knowledge.

  • Custom development planning (early development vs. manufacturing process or fit for purpose vs. optimized for efficiency).
  • Catalyst screening based on published scientific knowledge and more than 20 years of industrial experience in catalysis research.
  • Increased catalyst performance through mechanistic understanding.
  • Process optimization using high throughput DoE experimentation.
  • Process stability with Kinetic-DoE
  • Scale-up under best engineering consideration and representative scalable procedures.
  • Efficient technology transfer

Potent and High Potent Capabilities

Potent and High Potent Capabilities

Recent trends in drug development have seen a surge in demand for high potency production capabilities, a demand J-STAR is perfectly positioned to meet. Our state-of-the-art facility can help meet the needs of your high potency development programs as our subject matter experts ensure that we will handle your API programs with the highest level of care and safety to ensure success.

  • Extract-Walker Barrier Isolators: 2
  • 16 HPAPI Linear Glover Box Feet: 16
  • OEL Target (ng/m3): 10

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GMP API Manufacturing

Renowned in the industry for the flexibility and innovation of our processes, J-STAR can scale our chemistries to handle quantities from milligram to multi-kilos.

For volume exceeding the capacity of our NJ facilities, we can also leverage our parent company (Porton) to support larger scales spanning to commercial capacity.

  • Manufacture intermediates and impurities
  • Reference Standards
  • Non-GMP APIs
  • Raw Materials
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Peerless Customer Service

Led by a strong management team, J-STAR Research provides the highest level of scientific expertise, customer service and personal attention to every project.

Latest Equipment

J-STAR has one of the most comprehensive suits of laboratory, analytical, automation and PAT equipment in the industry.

Unmatched Expertise

The J-STAR Research team consists mainly of Ph.D. scientists with many years of practical experience in API synthesis, crystallization, analysis, process scale up, and cGMP delivery.

Highest Quality Results

Scientists are assigned and dedicated to each project based on their experience and skill sets in the respective subject matters.

Qualified Staff

Over 85% of our scientists hold a Ph.D. in organic chemistry, chemical engineering, material science, etc., and a large number of them have greater than 10-30 years of industrial experience.

State of the Art Facility

With two locations in New Jersey, J-STAR is conveniently located near the Newark airport.

Connect With Us

J-STAR Research helps pharmaceutical small molecule R&D programs succeed in all phases of development.