Oral solid dosage forms, mainly in the forms of tablets and capsules, still dominate the drug product market for their convenience to patients, not only for administration, but also safe and easy to compliance. In manufacturing of oral solid dosage forms, the flowability of active pharmaceutical ingredient (API), excipients used to formulate the API, and formulations play an important role, and should be assessed in the drug product development stage.

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Lipid-based formulation is proven to be one of the effective approaches to enhance solubility of poorly soluble drugs. At J-Star, our scientists are experienced in this solubilization method, and at the same time, applying it to liquid-filled capsules to simplify the process and stay away from the manufacturing issues of oral dosage forms.

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Roller Compaction is one of best processing methods to improve the flowability of API. Comparatively, direct compression which skips the granulation step is more cost- effective. Our enabling technique scan significantly improve the API particles flowability, make it possible to replace roller compaction process with direct compression process, and deliver quality products while simplifying the process.

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