Process Simplification Series No. 6: Direct Compression to Replace Roller Compaction via API Flowability Improvement
Oral solid dosage forms, mainly in the forms of tablets and capsules, still dominate the drug product market for their convenience to patients, not only for administration, but also safe and easy to compliance. In manufacturing of oral solid dosage forms, the flowability of active pharmaceutical ingredient (API), excipients used to formulate the API, and formulations play an important role, and should be assessed in the drug product development stage.
Read MoreDirect Compression to Replace Roller Compaction via API Flowability Improvement
Roller Compaction is one of best processing methods to improve the flowability of API. Comparatively, direct compression which skips the granulation step is more cost- effective. Our enabling technique scan significantly improve the API particles flowability, make it possible to replace roller compaction process with direct compression process, and deliver quality products while simplifying the process.
Read MoreEnabling Technology II. Dry Particle Coating for the Enhancement of Flowability and Bulk Density
Many active pharmaceutical ingredients (API) exhibit deficient bulk powder properties such as poor flowability, low bulk density, high cohesion, etc.
Read MoreEnabling Technology I. Co-Precipitation Technology (CPT) for the Enhancement of Flowability and Bulk Density
Direct compression (DC) process is the preferred method for tablet production because it is both simple and energy saving.
Read MoreEnhance Powder Flow Density and Flow By Dry Particle Coating
Many active pharmaceutical ingredients (API) exhibit deficient bulk powder properties such as poor flowability, low bulk density, high cohesion, etc.
Read MoreAdvantages of Co-precipitation Technology (CPT) Part I: Enhancement in Particle Morphology and Flow
Direct compression (DC) process is the preferred method for tablet production because it is both simple and energy saving.
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