Direct compression (DC) process is the preferred method for tablet production because it is both simple and energy saving. However, only a minority of active pharmaceutical ingredients (APIs) can be made into tablets by using DC because of the powder …
Wet granulation, dry granulation and direct blending are the three most common granulation processes for solid dosage form production in the pharmaceutical industry for decades. However, each of the three mentioned process has its drawbacks, among which, the requirement of …
For a drug substance administered via oral route, it should possess adequately aqueous solubility before passes through the gastrointestinal tract to complete the absorption, and then enters the blood steams for the pharmacological actions. Hence the solubility of a drug …
Oral solid dosage forms, mainly in the forms of tablets and capsules, still dominate the drug product market for their convenience to patients, not only for administration, but also safe and easy to compliance. In manufacturing of oral solid dosage …
Moisture-activated dry granulation (MADG) is an economical and novel granulation process which only requires minor amount of liquid (1-5%) to trigger the agglomeration of particles, uses the high shear granulator to spread out the moisture and then form uniform granules …
Lipid-based formulation is proven to be one of the effective approaches to enhance solubility of poorly soluble drugs. At J-STAR, our scientists are experienced in this solubilization method, and at the same time, applying it to liquid-filled capsules to simplify …
Roller Compaction is one of best processing methods to improve the flowability of API. Comparatively, direct compression which skips the granulation step is more cost- effective. Our enabling technique scan significantly improve the API particles flowability, make it possible to …
Many active pharmaceutical ingredients (API) exhibit deficient bulk powder properties such as poor flowability, low bulk density, high cohesion, etc. These deficiencies may cause some major issues for the performance of downstream processing including the blending, content uniformity, and tablet …
Many active pharmaceutical ingredients (API) exhibit deficient bulk powder properties such as poor flowability, low bulk density, high cohesion, etc. These deficiencies may cause some major issues for the performance of downstream processing thus affect content uniformity in final product.…
Direct compression (DC) process is the preferred method for tablet production because it is both simple and energy saving. However, only a minority of active pharmaceutical ingredients (APIs) can be made into tablets by using DC because of the powder …
Research studies show that the majority of API candidates in the development pipeline have a BCS Class II rating, which means those APIs need a solubilization strategy to promote the bioavailability to improve their chance of clinical success.
One commercially …
With the ability to develop both Drug Substance (DS) and Drug product (DP) under the same umbrella, our team enjoys a synergism absent in most CROs. The ability to bridge the DS/DP interface is a major competitive advantage, and we …