With advances in computational materials science and process simulation, computational applications are becoming an integral part of the drug development and manufacturing workflow.1,2 These methods facilitate easier navigation through the complex multidimensional space of pharmaceutical process development tasks. By combining …
Direct compression (DC) process is the preferred method for tablet production because it is both simple and energy saving. However, only a minority of active pharmaceutical ingredients (APIs) can be made into tablets by using DC because of the powder …
Many active pharmaceutical ingredients (API) exhibit deficient bulk powder properties such as poor flowability, low bulk density, high cohesion, etc. These deficiencies may cause some major issues for the performance of downstream processing including the blending, content uniformity, and tablet …
Drug discovery is an exceedingly complex process. Discovering a new chemical entity is in itself a huge accomplishment, which is often possible only after almost two decades of hard experimental work as well as advanced simulation efforts. Therefore, the next …