process-chemistry

Synthetic Route Design

Innovative Problem-Solving at Every Stage of Development

J-STAR’s team of 50 PhD process chemists have an impressive track record of designing cost effective and efficient synthetic routes to target molecules in support of the biopharmaceutical industry. We can partner with

High Pressure Chemistry Capabilities

High-Pressure Chemistry: When and Why?

Many chemical transformations require gases as reactants and perform better at high pressures. The decision to conduct a reaction at high pressure is sometimes an economic one, as it often requires smaller quantities of an

Continuous Flow Capabilities

Advantages of Continuous Flow over Traditional Batch Processes

Continuous flow offers many advantages over traditional batch processes. Often cited advantages are:

  • Greater control over mixing and mass transfer
  • Improved heat transfer
  • Can often avoid the need for very low temperatures
mmol H2 consumption of fR1-R3

Process Analytic Technologies (PAT) & Reaction Kinetics

What are Process Analytic Technologies (PAT)?

Process Analytic Technologies (PAT) allow the continuous monitoring of a reaction. Traditionally, reactions were run one at a time and often sampled at a specific time point to determine reaction progress. Although this method

Catalyst Screening

Statistics & Design of Experiments (DoE)

Rapid Development via Statistics and Design of Experiments (DoE)

Statistics and DoE are increasingly common in pharmaceutical development processes, from the manufacturing of RSMs and regulatory intermediates to API and the final drug product. The type of analysis can vary

High-Throughput Experimentation (HTE)

Advantages of High-Throughput Experimentation (HTE)

In recent years, High-Throughput Experimentation (HTE) – in which 100 or more experiments are conducted in parallel – has emerged as an important tool for the pharmaceutical industry at various stages of drug discovery and

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