Senior/Principal Scientist in Solid Form Selection/Preformulation Development

J-STAR Research, Inc. is a contract research organization (CRO) for pharmaceutical and biotechnology companies worldwide covering the entire spectrum of pharmaceutical development. It offers services in the areas of custom synthesis/contract research, API process and analytical research, cGMP synthesis, crystallization process development, solid form screening and selection, pre/early formulation, and drug product formulation and process development.

Title/Level
Senior/Principle Scientist (2 positions)

Key Responsibilities

• Lead development activities in phase-appropriate solid form selection and physicochemical characterization, such as powder X-ray diffraction, DSC, TGA, SEM, particle size, polarized light microscopy, moisture sorption analysis, solubility, dissolution and stability assessments.
• Understand solid form phase mapping of drug candidates to assist in crystallization process development.
• Develop formulations to support preclinical and Phase I studies including PK, PD, efficacy to support tox as well as first-in-human studies
• Designs experiments, strategies and workflows to improve bioavailability of poorly soluble drug molecules through enabling technologies.

Basic Requirements

• MS or PhD in Chemistry, Pharmaceutical Science or related field.
• 0-3 years of experience in solid form selection and preformulation development (solution, suspension, tablet, capsule, etc).
• Good understanding of solid-state chemistry of small molecule drug substances.
• Working knowledge of analytical techniques such as PXRD, TGA, DSC, PLM, DVS, HPLC, NMR and PSD.
• Strong communication, organization, and planning skills.