Summary: The Senior/Principal Scientist in Crystallization Process Development will develop crystallization processes to define and control final solid form of drug substances with desired solid-state attributes needed for optimum performance as well as drug intermediates for robust purification.
Develop innovative technologies focused on improving the efficiency of laboratory crystallization and to provide greater depth of process understanding with the application of Process Analytical Technology (PAT) and process modeling.
Carry out rational design and control of drug substance physical properties through particle engineering technologies and drug substance-drug product coprocessing.
MS or PhD in Chemistry, Chemical Engineering or related field.
At least three years of experience in crystallization process development or chemical process development.
Good understanding of solid-state chemistry of small molecule drug substances.
Working knowledge of analytical techniques such as PXRD, TGA, DSC, PLM, DVS, HPLC, NMR and PSD.
Experience within the pharmaceutical/biotechnology industry or CDMO industry is required. Experience in both is desirable, but not required.
Proven track record meeting aggressive targets as related to safe, timely and successful projects.
Knowledge and experience base of working in a c-GMP environment is preferable, but not required
Excellent written, verbal and presentation skills.
Strong communication, organization, and planning skills.
Experience in small molecule drug development is preferable, but not required.
Track record of scientific success as measured by publications and presentations.
Ability to prioritize and manage numerous activities simultaneously.
Ability to interact in an effective and appropriate manner with diverse population sets.
Experience in working on and positively contributing to scientific teams.
Ability to perform the physical requirements of the position.