Catalyst Screening & Enabling Technology

An Integrated Approach to Process Development

Our services in catalysis reaction development are differentiated through our unbiased integrated approach in the overall process development. We develop efficient catalytic reactions by utilizing the newest tools together with verified experimental high-throughput (HT) techniques, and scientific and industrial knowledge. We guide the customer through the recommended services and technologies, which depend on the project stage dependent needs.

High Throughput Screening Advantages

  • Comparable reactions within one screen (Same temperature profile, catalyst aging …).
  • Speed, i.e. finding suitable catalysts and reaction conditions quicker with access to one of the world’s largest commercial catalyst libraries.
  • Rapid and reliable go/no go decisions for route scouting.
  • Comprehensiveness, i.e. ensures to have identified the best catalyst and conditions through comprehensive screening.
  • Lead selection through HT-parallel optimization.

Typical Services Offered:

We offer all of our services as a standalone service or integral with our other services (Synthesis, process development, GMP manufacturing and crystallization).

Development planning: We provide an individualized work proposal that suits the needs of the customer (early development vs. manufacturing process or fit for purpose vs. optimized for efficiency).

Catalyst screening services: We design and conduct 96-well high-throughput catalyst screenings of reaction specific class variables based on published scientific knowledge and more than 20 years of industrial experience in catalysis research.

Increased catalyst performance: We optimize the catalyst performance through mechanistic understanding.

Process optimization: In an initial fast reaction optimization we map out all potential main 2-way and quadratic terms using high throughput DoE experimentation.

Process stability: We optimize the reaction further by utilizing Kinetic-DoE. This provides us with an endpoint analysis and the most stable operating range for the most statistically significant reaction parameter.

Scale-up: The reaction is being scaled-up under best engineering consideration and representative scalable procedures.

Efficient technology transfer: Throughout the collaboration the results are frequently communicated in written reports and through teleconferences. A final report will be issued at the end summarizing all relevant information.

A Wide Range of Catalytic Transformation

A fast and thorough development of a catalytic reaction involves all these steps. Depending on the needs, we also offer these services separately.

Our area of expertise covers a wide range of catalytic transformation, in particular:

Pressurized Reactions:
  • Amination
  • Carbonylation
  • Cyclopropanation, asymmetric
  • Hydroformylation
  • Hydrogenation
  • Deuteration (H/D exchange)
  • Debenzylation
Non Pressurized Reactions:
  • 1,2-alkylation of aldehydes, asymmetric
  • 1,4-conj. arylation or reduction
  • a-arylation
  • Baylis-Hillman
  • Borylation
  • Buchwald-Hartwig amination
  • C-O coupling (Aryl-ether formation) (Pd, Cu, Ni)
  • Cyanation
  • Direct arylation
  • Epoxidation, asymmetric
  • Heck reaction
  • Negishi coupling
  • Sonogashira coupling (Pd, Fe)
  • Suzuki coupling, asymmetric
  • Transfer hydrogenation, asymmetric
  • Ullmann coupling
  • Urea coupling

We develop the catalytic reactions considering the overall process of a multi-step synthesis (input material purity, cycle time, residual metal, impurity formation, remaining reagents and overall process economy to just name a few) taking the previous and following steps of a multi-step process into consideration.

Equipment

Capabilities