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Category : 2) Physical Property Based Crystallization Process Dev

Dr. Jian Wang, J-Star Research

Dr. Jian Wang is an expert in API crystallization, with comprehensive knowledge of the science and technologies required to meet the needs of small molecule drug development. She has...

Intelligent Cloud-Based Algorithms for Reducing Risk in Crystallization Process Development

By Dr. Mike Bellucci, XtalPi Inc Crystallization is the most widely used separation and purification process in the pharmaceutical industry.  The resulting crystal structure and corresponding crystal morphology isolated...

A Digital Mechanistic Workflow for Predicting Solvent-Mediated Crystal Morphology

By Prof. Kevin Roberts, University Of Leeds The crystallization of organic materials provides a common, energy efficient methodology for the purification and isolation of high value compounds such as...

Simulation aided solvent selection for robust impurity rejection by crystallization

By Dr. Yuriy Abramov, Exe. Director of CC&DS, J-Star Research Regulatory expectations for control of impurities in new drugs have been established through ICH guidelines. The most efficient approach...

A new approach to stere-opure atropisomeric molecules enabled by continuous flow-crystallization

By Dr. Michal Achmatowicz, Mirati Therapeutics Abstract: A new approach to stereopure atropisomeric molecules is enabled by a continuous flow-crystallization process. Continuous accumulation of the product under its optimal...

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