1) Combined In-Silico & Experimental Approach for Solid Form Screen & Selection & Characterization Archives - Pharma Crystallization Summit https://www.jstar-research.com/2022pcs/category/pcs2022/cmc-strategy-workshop/pcs2022cmc-01/ Conferences on pharmaceutical crystallization summit Sat, 27 Aug 2022 00:31:38 +0000 en-US hourly 1 https://wordpress.org/?v=6.0.3 https://www.jstar-research.com/2022pcs/wp-content/uploads/2022/05/cropped-PCS-Icon-35-CC-32x32.png 1) Combined In-Silico & Experimental Approach for Solid Form Screen & Selection & Characterization Archives - Pharma Crystallization Summit https://www.jstar-research.com/2022pcs/category/pcs2022/cmc-strategy-workshop/pcs2022cmc-01/ 32 32 Combined In-Silico & Experimental Approach for Solid Form Screen & Selection https://www.jstar-research.com/2022pcs/2022/07/16/combined-in-silico-experimental-approach-for-solid-form-screen-selection/ https://www.jstar-research.com/2022pcs/2022/07/16/combined-in-silico-experimental-approach-for-solid-form-screen-selection/#respond Sat, 16 Jul 2022 21:02:02 +0000 https://www.jstar-research.com/2022pcs/?p=2044 By Drs. Yuriy Abramov and Shanming Kuang, Center for Pharma Crystallization, J-Star Research Small molecule drug candidates tend to have different solid forms, including anhydrate, hydrate, solvate, salt, cocrystal and amorphous. Each form displays unique solid-state properties that may profoundly influence bioavailability, stability, manufacturability and other performance characteristics of the drugs. Therefore, it is critical […]

The post Combined In-Silico & Experimental Approach for Solid Form Screen & Selection appeared first on Pharma Crystallization Summit.

]]> Yuriy Abramov and Shanming Kuang,
Center for Pharma Crystallization, J-Star Research

Small molecule drug candidates tend to have different solid forms, including anhydrate, hydrate, solvate, salt, cocrystal and amorphous. Each form displays unique solid-state properties that may profoundly influence bioavailability, stability, manufacturability and other performance characteristics of the drugs. Therefore, it is critical to conduct solid-state research and choose the right crystal form for development based on properties including crystallinity, hygroscopicity, solubility, stability, processability and flowability. This workshop will focus on in-silico & experimental approaches for solid form screen & selection, which includes the rational, methodology and workflow. A case study that illustrates the selection process will be presented.

The post Combined In-Silico & Experimental Approach for Solid Form Screen & Selection appeared first on Pharma Crystallization Summit.

]]> https://www.jstar-research.com/2022pcs/2022/07/16/combined-in-silico-experimental-approach-for-solid-form-screen-selection/feed/ 0